Final steps in escort aptamer planning encompass man-made adjustment of your own truncated aptamer
Final steps in escort aptamer planning encompass man-made adjustment of your own truncated aptamer Further nuclease stabilization is achieved by substitution of 2?-OCHstep 3 for 2?-OH at purine positions. As the 2?-OCH3 moiety is not compatible with current SELEX process enzymes, this alteration must occur during chemical synthesis following evolution of a specific aptamer sequence. …